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Systems Biology and Bioengineering Undergraduate Research Experience

Publications, Conferences, and Patents: 

SyBBURE students are often involved in the creation of intellectual property and the dissemination of scientific findings. Below is the summary of journal articles, conference proceedings, and patent applications to which students contributed. This list does not include approximately 120 oral and poster presentations made by SyBBURE students (as first authors) at professional meetings and conferences outside of Vanderbilt.

Journal Articles:

1.        Faley S, Seale K, Hughey J, Schaffer DK, VanCompernolle S, McKinney B, Baudenbacher F, Unutmaz D, Wikswo JP, Microfluidic Platform for Real-Time Signaling Analysis of Multiple Single T Cells in Parallel, Lab Chip, 8:1700-1712 (2008)

2.        Gorman BR , Wikswo JP, Characterization of Transport in Microfluidic Gradient Generators, Microfluid. Nanofluid., 4:273-285 (2008)

3.        Harris M, Kim E, Weidow B, Wikswo JP, Quaranta V, Migration of Isogenic Cell Lines Quantified by Dynamic Multivariate Analysis of Single-Cell Motility, Cell Adh. Migr., 2:127-136 (2008)

4.        Seale KT, Reiserer R, Markov D, Ges I, Wright C, Janetopoulos C, Wikswo JP, Mirrored Pyramidal Wells for Simultaneous Multiple Vantage Point Microscopy, J. Microsc., 232, Pt 1:1-6 (2008)

5.        Elzie CA, Colby J, Sammons MA, Janetopoulos C, Dynamic Localization of G Proteins in Dictyostelium Discoideum, J. Cell Sci., 2597-2603 (2009)

6.        Darby S Moore M, Wikswo JP, Reiserer R, Friedlander T, Schaffer DK, Seale KT, A Metering Rotary Nanopump for Microfluidic Systems, Lab Chip, 10:3218-3226 (2010)

7.        Enders JR, Masasco CC, Kole ANguyen B, Sundarapandian S, Seale KT, Wikswo JP, McLean JA, Towards Monitoring Real-Time Cellular Response Using an Integrated Microfluidics-Matrix Assisted Laser Desorption Ionisation/Nanoelectrospray Ionisation-Ion Mobility-Mass Spectrometry Platform, IET Syst. Biol., 4:416-427 (2010)

8.        Markov DA, Manuel S, Shor L, Opalenik SR, Wikswo JP, Samson PC, Tape Underlayment Rotary-Node (TURN) Valves for Simple On-Chip Microfluidic Flow Control, Biomed. Microdevices, 12:135-144 (2010)

9.        Markov DA, Samson PC, Schaffer DK, Dhummakupt A, Wikswo JP, Shor LM, Window on a Microworld: Simple Microfluidic Systems for Studying Microbial Transport in Porous Media, J. Vis. Exp., 39:1741 (2010)

10.     Seale K, Faley S, Chamberlain J, Wikswo JP, Macro to Nano: A Simple Method for Transporting Cultured Cells from Milliliter Scale to Nanoliter Scale, Exp. Biol. Med., 235:777-783 (2010)

11.     Markov DA, Lu JP, Samson PC, Wikswo JP, McCawley LJ, Thick-Tissue Bioreactor as a Platform for Long-Term Organotypic Culture and Drug Delivery, Lab Chip, 12:4560-4568 (2012)

12.     Deng J, Dhummakupt A, Samson P, Wikswo JP, Shor LM, Dynamic Dosing Assay Relating Real-Time Respiration Responses of Staphylococcus aureus Biofilms to Changing Microbial Conditions, Anal. Chem., 85:5411-5419 (2013)

13.     Wikswo JP, Curtis EEagleton ZEvans BKole A, Hofmeister L, Matloff W, Scaling and Systems Biology for Integrating Multiple Organs-on-a-Chip, Lab Chip, 13:3496-3511 (2013)

14.     Srinivasan K, Wright GA, Hames N, Housman M, Aufdeheide KJ, Janetopoulos C, Delineating the Core Regulatory Elements Critical for Directed Cell Migration by Examining Folic Acid-Mediated Responses, J. Cell Sci., 126(Pt.1):221-233 (2013)

15.     Markov DA, Lillie EM, Garbett SP, McCawley LJ, Variation in Diffusion of Gases Through PDMS Due to Plasma Surface Treatment and Storage Conditions, Biomed. Microdevices, 16:91-96 (2014)

16.     Yan Y, Jiang L, Aufderheide KJ, Wright GA, Terekhov A, Costa L, Qin K, McCleery WT, Fellenstein JJ, Ustione A, Robertson JB, Johnson CH, Piston DW, Hutson MS, Wikswo JP, Hofmeister W, Janetopoulos C, A Microfluidic-Enabled Mechanical Microcompressor for the Immobilization of Live Single- and Multi-Cellular Specimens, Microsc. Microanal., 20:141-151 (2014)

17.     Wu SH, Hernandez N, Bain E, Bulow C, Gamse, J “Mediator subunit 12 coordinates intrinsic and extrinsic control of epithalamic development,” Dev. Biol., 385(1): 13-22 (2014)

18.     Byrd TF Hoang LTKim EG, Pfister ME, Werner EM, Arndt SE, Chamberlain JW, Hughey JJ, Nguyen BA, Schneibel EJ, Wertz LL, Whitfield JS, Wikswo JP, Seale KT, "The Microfluidic Multitrap Nanophysiometer for Hematologic Cancer Cell Characterization Reveals Temporal Sensitivity of the Calcein-AM Efflux Assay," Sci. Rep., 4:Article 5117 (2014)

19.     Hockemeyer K , Janetopoulos C, Terekhov A, Hofmeister W, Vilgelm A, Wikswo JP, Richmond A, "Engineered Three-Dimensional Microfluidic Device for Interrogating Cell-Cell Interactions in the Tumor Microenvironment," Biomicrofluidics, 8:044105-1-044105-12 (2014)

20.     Stow SS, Onifer TM,Forsythe JG, Nefzger H, Kwiecien NW,May JC, McLean JA, Hercules DM, “Structural Characterization of Methylenedianiline Regioisomers by Ion Mobility-Mass Spectrometry, Tandem Mass Spectrometry, and Computational Strategies. 2. Electrospray Spectra of 3 Ring and 4 Ring Isomers,” Analytical Chemistry, 87:6288-6296 (2015)

21.     Forsythe JG, Stow SS, Nefzger H, Kwiecien NW, May JC, McLean JA, Hercules DM, Structural Characterization of Methylenedianiline Regioisomers by Ion Mobility-Mass Spectrometry, Tandem Mass Spectrometry, and Computational Strategies: I. Electrospray Spectra of 2 Ring Isomers,” Analytical Chemistry, 86:4362-4370 (2014)

22.     Brown JA, Pensabene V, Markov DA, Allwardt V, Neely M, Diana Shi M, Britt CM, Hoilett OS, Yang Q, Brewer BM, Samson PC, McCawley LJ, May JM, Webb DJ, Li D, Bowman AB, Reiserer RS, and Wikswo JP, “Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor, Biomicrofluidics,” 9, 054124 (2015)

Conference Proceedings, Application Notes, and Other Publications:

1.        Hughey J , Wikswo JP, Seale KT, Intra-Microfluidic Pinocytic Loading of Human T Cells, IEEE/NIH Life Science Systems and Applications Workshop (LISSA), pp. 132-135  (2007)

2.        Kim EGR Sivasubramaniam P, Wikswo JP, Seale KT, Differential Optical Flow for Automated Cell Motility, MicroTAS Tech Digest 2008: Twelfth International Conference on Miniaturized Systems for Chemistry and Life Sciences, Locascio,LE, ed. Chemical and Biological Microsystems Society, San Diego, CA, October 12-16:1831-1833  (2008)

3.        Giron LC Hoang LHerrera-Flores AScherrer J, Seale K, Low Volume Bacterial Chemostat in Microfluidic Devices through the Use of Hexagonal Traps, Young Scientist, (2012)


4.        Seale KT, Rogers M, Reiserer RS, Embossed Foil Microfluidics for the Classroom, ASEE Southeast Section Conference,  (2014)


5.        Bowman A Scherrer J, Reiserer R, Note: A Single-Chamber Tool for Plasma Activation and Surface Functionalization in Microfabrication, Rev. Sci. Instr.  (2015)

Patents and Patent Applications:

1.        Helical Peristaltic Nanopump for BioMEMS Devices, Schaffer DK, Reiserer R, Darby S, Seale KT, Wikswo JP, US Patent Application Serial No. 61/365,040, converted to US 13/183,287 (Filed July 14, 2011)

2.        Metering Rotary Nanopump, Method of Fabricating Same, and Applications of Same, Seale KT, Wikswo JP, Schaffer DK, Reiserer RS, Darby S, US Patent Application Serial No. 13/183,287 (Filed July 14, 2011)

3.        Photolithographed Micro-Mirror Well for 3D Tomogram Imaging of Individual Cells, Seale K, Reiserer R, Wikswo JP, Rosenthal S, Chamberlain JWright C, Markov D, Janetopoulos C, United States Patent, 8,339,704 B2 (December 25, 2012)

4.        Organ on Chip Integration and Applications of the Same, Block III FE, Samson PC, Werner EM, Markov DA, Reiserer RS, McKenzie JR, Cliffel DE, Matloff WJ, Block, Jr. FE, Scherrer JRTidwell WH, Wikswo JP, International Patent Application No. PCT/US13/71026 (Filed November 20, 2013)

5.        Peristaltic Micropump and Related Systems and Methods, Gould PAHoang LTScherrer JMatloff WJ, Seale KT, Curtis EL, Schaffer DK, Hall DJKole A, Reiserer RS, Tidwell WH, Samson PC, Wikswo JP, National Phase Patent Application Serial No. 13/877,925 (Filed July 16, 2013)

6.        Improved RPPM/RPV Designs and Implementations of Same, Wikswo JP, Block III  FE, Samson PC, Markov DA, Resierer RS, Matloff WJTidwell WH, US Provisional Patent Application Serial No. 61/808,455 (Filed April 4, 2013)

7.        ZebraSpin: A method of orienting zebrafish embryos for treatment and microscopy, Bulow C, Schaffer D, Seale KT, US Provisional Patent Application Serial No. 61/994,366 (Filed May 16, 2014)

8.        Systems And Methods For Serial Treatment Of A Muscular-Skeletal Deformity, Schoenecker J, Braman N, Houston A, Mendive M, Miao S. US Provisional Patent Application Serial No. 62/222,972 (Filed September 24, 2015)

9.        Rheological Flow Assay for Diagnosis and Monitoring of Disease, Cyr K, (2015, pending filing)